A study of stability of 10% Povidone-Iodine solution

Abstract

The stability testing program of 10% w/v buffered solution was designed to assess the Influence of pharmaceutical buffers, sources of solvent and packaging materials on the degradation of PVP-I solution. The quantitative analysis was performed by determining of available iodine as official in USP XX.It was found that, at the same buffer concentration and the initial pH of 5.5, 10% w/v PVP-I solution in phosphate buffer was more stable than in acetate or citrate buffer whereas the solution in citrate buffer could maintain pH better than in the other two. The solvent should be distilled water. The solution of 10% w/v PVP-I buffered solution should be filled in polyethylene bottle. Available iodine decreased rapidly at the initial state of the degradation. Then, the appearance degradation rate was gradually decreased. Finally, the degradation was postulated To be zero order reaction. Thus, in case of 10% w/v PVP-I solution formulation in buffer, PVP-I should be excessively added to maintain the quantity of available iodine after initial Rapid degradation.