Novelty in Analytical Chemistry for Innovation of Detection

Abstract

Analytical chemistry is the one of the most importance not only to all branches of chemistry but also to all the biological sciences, to engineering, and, more recently, medicine, public health, food, environment and the supply of energy in all forms. Therefore, the developments of novel detection methods play an important role to obtain both qualitative analysis and quantification of the chemical or biomolecule components of natural and artificial materials. This work has been separated into 3 groups for finishing the novelty in detection methods. First, novel nanomaterials-based or nanocomposite chemical sensors based on nanomaterial/conducting polymer will be prepared and used to modify the electrode surface for sensitive electrochemical and/or optical detection of chemicals and biomolecules. The bioreceptor functionalization will be applied if it is necessary. Under the optimal conditions, the proposed system will be used for sensitive detection of target analytes (e.g. heavy metals, pesticides, food contaminants and biomolecules). This approach is an alternative tool for environmental monitoring, food inspection as well as clinical diagnosis. Second, the paper-based device is proposed. They have the potential to be good alternatives for point-of-care testing because they are portable, easy to use, require only a small volume of sample and provide rapid analysis. To create the detection method for lab-on-paper, colorimetric and electrochemical detection are proposed. These provide the benefits of simplicity, speed, low cost, and portability for applying to various applications. Last, a simple microfluidic or sequential injection system for chemical or biomedical analysis will be developed. Exploiting a microfluidic or sequential injection system, short analysis times can be achieved with high analytical performances, in addition, only small amount of samples and reagents are required, which is beneficial for samples which are expensive or limited, especially biological samples. Moreover, microfluidic or sequential injection analysis holds great promise for high-throughput analysis and screening, which offers an alternative platform for analysis and would be an ideal tool for a portable analysis system for clinical diagnosis.