Abstract:
Satellite glial cells (SGCs) have an important role of the trigeminal ganglion (TG) neurons. Several studies found that role of SGCs affect the TG response occurring release various inflammatory mediators. This studies purpose role of SGCs on electrical response property of the small-to-medium sized and large sized TG neurons in the presence of capsaicin or CGRP. The experiments divide to primary co-culture TG neurons (TG+SGCs) and primary pure culture neurons (only TG). The result showed that co culture group was significantly lower threshold and lower rheobase than pure culture group in normal condition. The presence of CGRP and capsaicin, the result showed co culture group was significantly lower threshold and lower rheobase than pure culture group. Additionally, co culture group was higher elicited number of spikes than pure culture group in small-to-medium sized TG neurons. Thus, primary culture neurons that without SGCs causing reduce electrical response TG neurons. This study reveal that SGCs can modulate the neuronal excitability and pain sensation in the trigeminovascular nociceptive system deserve further exploration.
