Increase dissolution rate of ibuprofen through solid dispersion

Abstract

Ibuprofen solid dispersions were prepared using polyethyleneglycol (PEG) 4000, PEG 6000, PEG 20000, mannitol, urea and polyvinylpolypyrrolidone (PVPP) as carriers. The influence of type and amount of carriers used in the preparation of solid dispersion on the dissolution characteristic of ibuprofen were investigated. The carriers which could be used to prepare ibuprofen solid dispersion by fusion method were limited to only the PEG series due to the low melting point of the drug. All the above mentioned carriers were used as the carriers in the preparation of ibuprofen solid dispersion by solvent method. Polyvinylpyrrolidone (PVP) K-30 and K-90 had also been tried and the results indicated that PVP series could not be used as carriers for preparing ibuprofen solid dispersions by both fusion and solvent methods. The fusion method was easier, less time consuming and more economical to prepare than the solvent method Ibuprofen solid dispersions were prepared using polyethyleneglycol (PEG) 4000, PEG 6000, PEG 20000, mannitol, urea and polyvinylpolypyrrolidone (PVPP) as carriers. The influence of type and amount of carriers used in the preparation of solid dispersion on the dissolution characteristic of ibuprofen were investigated. The carriers which could be used to prepare ibuprofen solid dispersion by fusion method were limited to only the PEG series due to the low melting point of the drug. All the above mentioned carriers were used as the carriers in the preparation of ibuprofen solid dispersion by solvent method. Polyvinylpyrrolidone (PVP) K-30 and K-90 had also been tried and the results indicated that PVP series could not be used as carriers for preparing ibuprofen solid dispersions by both fusion and solvent methods. The fusion method was easier, less time consuming and more economical to prepare than the solvent method higher dissolution rate of ibuprofen than the unsieved portion. Storage of pure ibuprofen and the 1:4 ibuprofen: PEG 4000 solid dispersion prepared by fusion method outside the desiccator for ten weeks showed no significantly change either in the content or in the dissolution characteristic of ibuprofen. Considering the ease of preparation, economy, and improving of the dissolution characteristic of ibuprofen, the best system in this investigation is the ibuprofen solid dispersion using PEG 4000 as the carrier in the ratio of 1:2 prepared by fusion method.