Synthesis and characterisation of calcium citrate nanoparticles for metformin delivery

Abstract

In this research, a novel metformin encapsulated calcium citrate nanoparticles were synthesized via chemical precipitation method. The products were characterized by thermal gravimetric analysis (TGA) and scanning electron microscope (SEM). The optimum condition was 4:1 mole ratio of calcium citrate to metformin and using absolute ethanol to facilitate precipitation. The maximum loading capacity of metformin is 2.96% . This procedure could be used to formulate metformin encapsulated calcium citrate as novel drug delivery system.