Development of magnetic chitosan nanoparticles

Abstract

The present work focuses on preparing the magnetic nanoparticles and chitin- chitosan hybrids materials via secondary forces and covalent bond in water-based system. In the first part, the hybridization via physical interactions and factors related to colloidal stabilization is clarified. The work shows that particle size, surface charge, and morphology can be controlled by pH and polarity of the surrounded environment. The work also extends to implement for genomic DNA isolation. In the second part, the work shows the simple and effective synthesis pathway to fabricate magnetic nanoparticles and chitin-chitosan hybrids materials via covalent bond through simple silane coupling reaction. The epoxy functional group of silane coupling agent is ready to react with hydroxyl group of chitin/chitosan. In the last part, another potential approach of hydrogel incorporated magnetic nanoparticles is to achieve hydrogel/aerogel responsive to the magnetic field. The high porosity and surface area of aeroges is expected to enhance the ability to adsorb substances.