Investigation on tablett cisintegrating properties of the fruitpulp of Scaphium macropodum beumee

Abstract

Disintegrating properties of Scaphium powders derived from the fruitpulp of Scaphium macropodum Beumee were investigated in comparison with commonly used disintegrants such as corn starch, Kollidon CL[superscript (R)], Ac-Di-sol[superscript (R)], Explotab[superscript (R)], ECG 505[superscript (R)], and L-HPC. The concentrations of various disintegrants used were 0.5, 1, 3, and 5% levels in both water insoluble (dibasic calcium phosphate dehydrate) and water solube (∝-lactose monohydrate) directly compressible diluents. Tablets were prepared by direct compression method at four different compressional forces of 1200, 1800, 2400, 3000 pounds. The effects of Scaphium powder on the dissolution rate of hydrochlorothiazide tablets containing water insoluble and water soluble diluents were also determined. Water insoluble tablets with Scaphium powders exhibited higher rate and volume of water uptake than those with corn starch but lower than those with the other disintegrants. For water soluble tablets, their rates and volumes of water uptake at low concentration of Scaphium powders were faster than those at high concentration. Scaphium powders possessed good disintegrating properties. The disintegration time of water insoluble tablet system containing Scaphium powders at concentrations of 0.5 and 1% were depended on compressional force. The disintegration time of tablets were shorter than those with corn starch and similar to those with L-HPC and Kollidon CL[superscript (R)] as disintegrants. At concentration of 5%, the disintegration time of tablets became longer than those of 1-3% levels. Scaphium powders exhibited good disintegrating properties at concentration of 0.5% in water soluble system. The tablets with Scaphium powders showed disintegrating characteristics as same as the tablets with superdisintegrants e.g., Explotab[superscript (R)] or Ac-Di-Sol[superscript (R)] by disruption into primary particles. It was also found that Scaphium powder enhanced dissolution rate of hydrochlorothiazide tablets at low concentration.