Chemical constituents of stem barks of Croton robustus Kurz. and their biological activity

Abstract

Air-dired and ground barks of Croton robustus Kurz. used in this study. They were extracted by hexane, chloroform and methanol, respectively. The hexane crude extracts was separated by column chromatography, and gave three compounds. The structures of these compounds were established on the basis of physical properties, spectroscopic data and chemical reaction. The three compounds were two trachylobane diterpenoids; trachyloban-19-oic acid (1) and trachyloban-19-ol (3) and one cembrane diterpenoid; poilaneic acid (2). Moreover it is the first report of a trachylobane diterpeniod from the Croton species.